If you fold the diagram below into the shape of a cube and add the 4 corresponding diagonals, rows, or columns around the 4 faces it will give you the answer (you exclude the top and bottom face)
A Diagonal might start off as (2+2+2) + (2+3+5) + (2+4+5) etc
A Row could start off as (2+1+6) + (2+5+3) + (4+5+2) etc
Of course this in no way predicts what the ultimate question of life the universe and everything is, even if you know the answer.
Of course, you could always cheat and just search google: Google Search for the answer to life the universe and everything